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KMID : 0882419930450050670
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Korean Journal of Medicine
1993 Volume.45 No. 5 p.670 ~ p.675
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A Case Report of Anti-Neutrophil Cytoplasmin Autoanibody Positive Polyarteritis Nodosa
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조원경
제수정/최정은/정해혁/이미화/홍진석/박홍동/박정식/김대원
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Abstract
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nti-neutrophil cytoplasmic autoantibodies are serologic marker for various disease, ranging from multisystem vasculitis, such as Wegner's granulomatosis and polyarteritis nodosa, to renal-limited disease (that is, idiopathic crescentic
glomerulonephritis) These ANCA-associated diseases share the pathologic feature of necrotizing vascular inflammation with scant immune deposition. In vitro studies suggest that these diseases also have a common immunopathogenesis mediated by
ANCA-induced neutrophil activation.
We experienced a case of ANCA positive polyarteritis nodosa.
The physical exammination of abdomen showed mild direct tenderness on the right upper
quadrant. Laboratory studies on admission revealed leukocytosis, elevated ESR, proteinuria,
hematuria, and elevated alkaline phosphatase. Liver bipsy and renal biopsy revaled
characterstic findings of Polyarteritis Nodosa. Serologic test for ANCA showed central type
with 1:1280 of titer. The patients was treated with prednisolone and oral cyclophosphamide
but the disease progressed to end-stage renal disease.
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KEYWORD
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